Scientific Breakthrough: Scientists Create Gel That Can Repair and Regenerate Tooth Enamel
In a major stride for restorative dentistry, scientists from the University of Nottingham, working with an international research team, have developed a protein-based gel capable of repairing and regenerating tooth enamel. This discovery, published in Nature Communications, potentially offers a long-lasting preventive and restorative option, especially given that enamel degradation contributes to tooth decay in nearly half of the global population.
The material, developed by the university’s School of Pharmacy and Department of Chemical and Environmental Engineering, helps to remineralize, strengthen enamel, and prevent future decay.
How This Innovative Gel Works
The new gel is a unique material that is fluoride-free and mimics the natural proteins that guide the formation of tooth enamel during infancy. Its mechanism of action differs significantly from traditional fluoride-based treatments:
Application: The gel is applied much like a fluoride varnish, creating a thin, durable layer that fills microscopic holes and cracks in demineralized enamel.
Active Scaffold: The gel then acts as a potent natural scaffold, actively drawing calcium and phosphate ions from the patient's saliva.
Epitaxial Mineralization: This process, called epitaxial mineralization, enables the growth of new mineral that integrates seamlessly and in an organized manner with the underlying architecture of the existing enamel.
Dr. Abshar Hasan, the lead author of the study, explained that when their material is applied to eroded or demineralized enamel, it "promotes crystal growth in an integrated and organized manner, restoring the architecture of natural healthy enamel." This effectively restores the strength and resilience of natural enamel.
Impact and Commercialization
With the ability to replicate the complex architecture of natural enamel, this bio-inspired material has the potential to revolutionize how dentists treat small cavities and tooth erosion, offering a far more effective solution than current methods.
The research team has moved quickly towards commercialization. They have partnered with Mintech-Bio, a University of Nottingham spin-off company, and hope to have a first product available next year. This innovation holds immense potential to soon be helping patients worldwide.
Original Article Details
Original Title: Scientists create gel that can repair and regenerate tooth enamel
Source: Oral Health Group
Publication Date: November 5, 2025